The first step is to create a dataset, if you haven't created it already. This code generates an empty dataset in the account, which will have a name and description as provided to the datasets.create method:

from mapbox import Datasets
import json
datasets = Datasets(access_token={secrettoken})
create_resp = datasets.create(name="Bay Area Zips", 
              description = "ZTCA zones for the Bay Area")