As the functionality of JavaScript expands, the need for third party frameworks and even transpilers starts to drop off. The language itself replaces many of these tools. The end game for tools like jQuery is that they are no longer required as they have been absorbed into the ecosystem. For many years the velocity of web browsers has been unable to keep pace with the rate of change of people's desires.

There is a large effort behind the next version of AngularJS but great efforts are being made to align the new components with the upcoming web component standards. Web components won't fully replace AngularJS but Angular will end up simply enhancing web components.

Of course the idea that there won't be a need for any frameworks or tools is ridiculous. There is always going to be a new method of solving a problem and new libraries and frameworks will show up. The opinions of people on how to solve problems is also going to differ. That's why there is space in the market for the wide variety of MVVM frameworks that exist.

Working with JavaScript can be a much more pleasant experience if you make use of ES6 constructs. There are a couple of possible approaches to doing so, which of these is best suited to your specific problem is a matter for closer investigation.